However, ongoing debate centers on whether the benefits of uric acid-lowering therapy stem from decreased uric acid levels or the inhibition of XO activity
The increase in central neural activity is believed to be a consequence of an alteration in the normal balance between excitation and inhibition in nerve transmission, potentially due to a diminution of GABAergic inhibition 50,51,52
Yang JK, Feng Y, Yuan MY, Yuan SY, Fu HJ, Wu BY, Sun GZ, Yang GR, Zhang XL, Wang L, Xu X (2006) Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS
GCL comprises a catalytic (GCLC) and a modifier (GCLM) subunit, and its activity can be readily inhibited with DL-buthionine-sulphoximine (BSO) [13]
We found no sex differences on 90-day functional outcome